Phase 2b Study of Taxol Plus Sorafenib or Placebo in Patients With Advanced Breast Cancer
Status unconfirmed · Phase 2 · Has a placebo group
Conditions studied: Breast Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Giving paclitaxel together with sorafenib may kill more tumor cells. PURPOSE: This randomized phase II trial is studying how well paclitaxel works when given together with or without sorafenib in treating patients with locally recurrent or metastatic breast cancer.
Key facts
- Study ID
- NCT00499525
- Run by
- Northwestern University
- People needed
- 180
- Starts
- 2007-06-01
- Expected to finish
- 2022-12-01
- Last updated by the study team
- 2019-05-03
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Northwest Alabama Cancer Center, PC - Muscle Shoals — Muscle Shoals, Alabama, United States
- Highlands Oncology Group - Fayetteville — Fayetteville, Arkansas, United States
- Pacific Cancer Medical Center, Incorporated — Anaheim, California, United States
- Pacific Coast Hematology/Oncology Medical Group, Incorporated — Fountain Valley, California, United States
- Desert Hematology-Oncology Medical Group, Incorporated — Rancho Mirage, California, United States
- Sutter Cancer Center — Sacramento, California, United States
- Cancer Prevention and Treatment Center at Dominican and Watsonville Community Hospital — Soquel, California, United States
- Study site — St. Helena, California, United States
- Helen and Harry Gray Cancer Center at Hartford Hospital — Hartford, Connecticut, United States
- Eastern Connecticut Hematology and Oncology Associates — Norwich, Connecticut, United States
- Medical Oncology and Hematology, PC at Harold Leever Cancer Center — Waterbury, Connecticut, United States
- George Washington University Cancer Institute — Washington D.C., District of Columbia, United States
- Pasco Hernando Oncology Associates, PA - Brooksville — Brooksville, Florida, United States
- Pasco Hernando Oncology Associates, PA - New Port Richey — New Port Richey, Florida, United States
- Northeast Georgia Cancer Care, LLC - Medical Oncology — Athens, Georgia, United States
- Mountain States Tumor Institute at St. Luke's Regional Medical Center — Boise, Idaho, United States
- Hematology-Oncology Associates of Illinois — Chicago, Illinois, United States
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University — Chicago, Illinois, United States
- Decatur Memorial Hospital Cancer Care Institute — Decatur, Illinois, United States
- Cancer Institute at Alexian Brothers — Elk Grove Village, Illinois, United States
- Medical and Surgical Specialists, LLC — Galesburg, Illinois, United States
- Hinsdale Hematology Oncology Associates — Hinsdale, Illinois, United States
- Midwest Center for Hematology/Oncology — Joliet, Illinois, United States
- Kellogg Cancer Care Center — Oak Park, Illinois, United States
- Hematology/Oncology of the North Shore at Gross Point Medical Center — Skokie, Illinois, United States
Full record on ClinicalTrials.gov
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