Effects of Garlic Supplements on Opioids in Healthy Volunteers
Completed · Phase 4
Conditions studied: Healthy, No Evidence of Disease
In brief
RATIONALE: Garlic supplements may alter the pharmacokinetics of oxycodone, thereby affecting its effectiveness as an opioid analgesic for the relief of moderate or severe pain. PURPOSE: This randomized phase 4 trial is studying how garlic supplements may change the pharmacokinetics of oxycodone and its analgesic and side effects in healthy volunteers.
Key facts
- Study ID
- NCT00499460
- Run by
- Fred Hutchinson Cancer Center
- People needed
- 15
- Starts
- 2006-11-01
- Expected to finish
- 2008-08-01
- Last updated by the study team
- 2017-04-07
Who can join
Age: 21 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy volunteer
- Body mass index 20-32
You may not qualify if…
- Not pregnant
- No history of cardiopulmonary, liver, renal, endocrine, neurologic, or psychiatric disease
- No anemia
- No known adverse reactions to opioids, benzodiazepines, cardiac glycosides, or garlic supplements
- No known allergy or hypersensitivity to sulfur-containing food or drugs
- No significant gastrointestinal intolerance to lactose in dairy products
- No recent history of alcohol or substance abuse
- No history of or concurrent heavy daily consumption of allium vegetables (i.e., garlic, shallots, leeks, and chives)
- No handicaps due to visual and hearing impairments
- No resting heart rate < 50 beats per minutes
- No abnormal cardiac rhythm by EKG
- No unusually sensitive response or resistance to pain stimulation (Cold Pressor Test)
- Must be right handed
- No color blindness
- No history of learning disabilities or dyslexia
- Must be literate and proficient in English
- Must be a nonsmoker
- No concurrent medication except oral contraceptives
- No concurrent grapefruit or grapefruit juice
- No other concurrent over-the-counter herbal products or herbal tea
Where it is running
- Fred Hutchinson Cancer Research Center — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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