A Comparison of Two Cognitive Batteries in People With Schizophrenia
Completed · Not applicable
Conditions studied: Schizophrenia, Schizoaffective Disorder
In brief
The investigators will compare the test-retest reliabilities of two cognitive batteries in people with schizophrenia: Cognitive Drug Research Computerized Cognitive Assessment System ("CDR") and MATRICS Consensus Cognitive Battery ("MCCB"). The investigators hypothesize that there will be a statistically significant difference in the test-retest reliabilities between MCCB and CDR. In addition, the investigators hypothesize that each of the two batteries will better measure certain areas of cognition. The investigators also hypothesize that scores from both batteries will correlate with quality of life scores, and that there will be a significant difference between the correlations of MCCB and CDR. The investigators hypothesize there will be a significant difference in patients' self-reported tolerability and satisfaction of the MATRICS versus CDR assessments. Lastly, the investigators hypothesize that there will be a significant difference in the MATRICS versus CDR batteries with respect to an administrator-rated score of practicality. Approximately 32 subjects will enroll in the study. Following consent and eligibility screening (visit 1) and baseline clinical assessment and training in the use of the CDR battery (visit 2), subjects will be randomized into one of two groups for visits 3 and 4. One group will complete the CDR and then MCCB in visit 3, as well as the Tolerability Scale for each battery. The other group will complete the batteries in reverse order during visit 3. Each group will complete both batteries again in reverse order for visit 4. Randomization will be done in blocks of 2. After completion of every 4 subjects, study administrators will complete the Practicality Scale for each battery.
Key facts
- Study ID
- NCT00499044
- Run by
- North Suffolk Mental Health Association
- People needed
- 32
- Starts
- 2007-12-01
- Expected to finish
- 2009-03-01
- Last updated by the study team
- 2009-11-26
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Women and men aged 18-65 with DSM-IV diagnosis of schizophrenia or schizoaffective disorder (depressed type) by diagnostic interview and chart review.
- Clinically stable on a stable dose of antipsychotic medication for at least one month; no current active suicidal ideation.
- Not treated with investigational medication in the past 30 days.
- Competent to provide informed consent.
You may not qualify if…
- Diagnosis of dementia, neurodegenerative disease, seizure disorder, current substance abuse or dependence disorders, including alcohol, active within the last 3 months or any Axis I DSM-IV diagnosis other than schizophrenia or schizoaffective disorder (depressed type).
- Serious illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurological, or hematological disease that is not stabilized such that hospitalization for treatment of that illness is likely within the next two months.
- Patients who, in the investigator's opinion, pose a current severe homicide or suicide risk.
- History of multiple head injuries with neurological sequelae or a single severe head injury with lasting neurological sequelae.
Where it is running
- Freedom Trail Clinic, Massachusetts General Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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