The Effect of Administration on N-Acetylcysteine on Serum Creatinine Levels in Patients With Chronic Kidney Disease

Completed · Not applicable

Conditions studied: Chronic Kidney Disease

In brief

Primary outcome: Serum creatinine change at 4 hours and 48 hours following 4 doses of N-acetylcysteine (total 4800 mg) compared to baseline serum creatinine. Secondary outcome: Serum Cystatin C change at 4 hours and 48 hours post 4 doses of N-acetylcysteine compared to baseline serum Cystatin C.

Key facts

Study ID

NCT00498342

Run by

University of Vermont

Starts

2007-06-01

Expected to finish

2008-02-01

Last updated by the study team

2008-02-18

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Estimated GFR 10-59 ml/min/1.73m2 by 4 variable MDRD equation
• Less than a 10% difference between the baseline creatinine and the recruitment creatinine obtained within 3 months of the trial

You may not qualify if…

• Unable to give informed consent
• Unwillingness to return for follow-up blood sampling
• Unstable renal function
• Subjects taking H2-blockers

Where it is running

• University of Vermont /Fletcher Allen Health Care, Inc. — Burlington, Vermont, United States

Full record on ClinicalTrials.gov

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