Genes Causing Ebstein's Anomaly

Completed

Conditions studied: Heart Septal Defects, Ventricle, Heart Defects, Congenital, Double Outlet Right Ventricle, Truncus Arteriosus, Persistent

In brief

This study will investigate Ebstein's anomaly, a congenital abnormality of the tricuspid valve of the heart and try to identify the genetic origins of the disease. Adults and children 2 years of age and older with Ebstein's anomaly and healthy volunteers may be eligible for this study. Participants undergo the following procedures: * Blood tests: Three tube of blood will be collected, with the total amount limited to about half a teaspon for each two pounds of body weight. * Saliva sample collection: A small amount of saliva is collected by spitting into a sterile container. * Oral (cheek) swab: Cells are collected from the mouth using a soft brush to swab the inside lining of the cheek. * Electrocardiogram: The electrical activity of the heart is recorded using electrodes placed on the chest. * Echocardiogram: Heart function is assessed using ultrasound.

Key facts

Study ID

NCT00497705

Run by

National Heart, Lung, and Blood Institute (NHLBI)

Starts

2007-07-03

Last updated by the study team

2017-07-02

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• There are no exclusion criteria. This may allow us to discover previously unknown relationships between Ebstein's anomaly and other diseases.

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
• Republican Scientific and Clinical Cardiology Center — Republic of Belarus, Belarus
• Amosov Institute of Cardiovascular Surgery — Kyiv, Ukraine

Full record on ClinicalTrials.gov

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