Hyperbaric Oxygen Treatment in Patients With White Matter Hyperintensities

Completed

Conditions studied: Neurological Impairments, Leukoencephalopathies

In brief

The primary purpose of this study is to assess whether hyperbaric oxygen treatment improves neurological function in patients who exhibit white matter hyperintensities on MRI examination. The secondary goal of this study is to determine if it is possible using MRI to discern a difference in perfusion of central nervous system tissue in regions of white matter hyperintensities after hyperbaric oxygen administration as compared to hyperbaric air.

Key facts

Study ID

NCT00497432

Run by

St. Luke's Hospital, Chesterfield, Missouri

People needed

20

Starts

2007-07-01

Expected to finish

2012-11-01

Last updated by the study team

2013-05-31

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Over 50 years of age
• White Matter Hyperintensities on MRI of brain
• Two or more symptoms and/or Neurological impairments e.g. gait disturbance, dysequilibrium, decline in cognitive function, upper motor neuron deficit, dysmetria, hyper-reflex or unilateral increase in muscle tone

You may not qualify if…

• Contraindications to hyperbaric oxygen therapy e.g. pulmonary emphysema or bullae, claustrophobia, seizure disorder
• Inability of the patient to tolerate pressurization e.g. eustachian tube dysfunction
• Extreme cognitive impairment
• Major Depression
• Other uncontrolled co-morbidities e.g. diabetes, hypertension, thyroid disorders, carotid artery stenosis (over 70%), renal or hepatic dysfunction
• History of brain tumor, head trauma, electroshock therapy,brain irradiation or migraine headaches

Where it is running

• St. Luke's Hospital — Chesterfield, Missouri, United States
• Mallinckrodt Institute of Radiology/Washington University Medical School — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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