Urinary Prostaglandin E Metabolite (PGE-M), A Metabolite of Prostaglandin E2 (PGE2): A Novel Biomarker of Crohn's Disease Activity

Completed · Not applicable

Conditions studied: Crohn's Disease

In brief

The purpose of this study is to determine whether urinary PGE-M levels correlate with Crohn's disease activity and to compare how well urinary PGE-M correlates with other non-invasive biomarkers of disease activity such as C-reactive protein (CRP) and fecal calprotectin.

Key facts

Study ID

NCT00496548

Run by

Vanderbilt University Medical Center

People needed

159

Starts

2007-08-01

Expected to finish

2015-12-01

Last updated by the study team

2017-05-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Outpatient male or female 18 years or older
• Confirmed diagnosis of Crohn's disease
• Informed consent obtained
• Able to give blood, urine and stool samples
• Willing to undergo a diagnostic colonoscopy as part of routine Crohn's disease care

You may not qualify if…

• Unable to give consent
• Ulcerative colitis
• Does not meet inclusion criteria
• Pregnant

Where it is running

• GI Clinical Research; Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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