The Pharmacokinetics of Opioids and Sedative/Hypnotics During Selective Cerebral Perfusion

Completed

Conditions studied: Aortic Aneurysm

In brief

There is a need to understand how long anesthetic drugs last in the brain during surgery on the ascending aorta or aortic arch. Drugs can have a prolonged effect when blood temperature is made cold therefore the influence of temperature needs to be studied. This type of surgery allows us to answer questions about how anesthetic drugs behave when they are given during a routine portion of surgery. Patients will be provided with anesthetic drugs during surgery while on a heart lung machine. After the drug is injected into the heart lung machine it will be delivered to the brain to provide more sleep and pain relief. Immediately after the injection of anesthetic drugs, blood samples will be taken from an existing intravenous line in the neck and plasma drug concentrations measured. This will help us to understand how long drugs last in the brain during this type of surgery.

Key facts

Study ID: NCT00494598
Run by: Columbia University
People needed: 6
Starts: 2007-03-01
Expected to finish: 2007-06-01
Last updated by the study team: 2013-08-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

The study population will comprise individuals who have elected to undergo aortic arch surgery or re-operative cardiac surgery requiring selective cerebral perfusion.
Patients will be treated according to the standard medical practice of Columbia University Medical Center.
Patients will be within 21 to 90 years of age.

You may not qualify if…

Patients having known hypersensitivity to the anesthetic agents being studied will be excluded.

Where it is running

Columbia University College of Physicians and Surgeons — New York, New York, United States

Full record on ClinicalTrials.gov

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