Use of Mucomyst to Ameliorate Oxidant Stress in Diabetics With Proteinuria

Completed · Not applicable

Conditions studied: Diabetes, Proteinuria

In brief

The study will look at the effect of 30 days of treatment of 15 diabetics with proteinuria with N-acetylcysteine ( Mucomyst ) at a dose of 1 gm twice a day by mouth. The primary outcome that will be measured is change in the oxidant stress as measurable by changes in the serum level of isoprostane, Glutathione peroxidase, aconitase and Total oxidant stress. Secondary outcomes measured will be changes in proteinuria and kidney function as measured by spot urine pr/cr and estimated GFR by MDRD formula.

Key facts

Study ID

NCT00493727

Run by

US Department of Veterans Affairs

People needed

15

Starts

2006-09-01

Expected to finish

2007-12-01

Last updated by the study team

2008-05-19

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diabetic with proteinuria

You may not qualify if…

• Allergy to mucomyst and pt on dialysis

Where it is running

• VA Medical Center, Dayton — Dayton, Ohio, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.