A Study to Determine Whether Perioperative Energy Dynamics Correlates With Postoperative Outcomes

Recruiting now

Conditions studied: Abdominal Cancer, Pelvic Cancer

In brief

To validate a new method for assessing perioperative risk in the cancer patient undergoing major cancer surgery. In this proposed study researchers will: 1. Measure preoperative energy reserve capacity (fitness) 2. Determine if postoperative morbidity is a function of perioperative cardiopulmonary gas exchange metabolism

Key facts

Study ID

NCT00493688

Run by

M.D. Anderson Cancer Center

People needed

200

Starts

2005-10-30

Expected to finish

2028-10-30

Last updated by the study team

2026-07-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants 18 years of age or older.
• Participants with newly diagnosed esophageal and lung cancer undergoing neoadjuvant chemotherapy, radiation therapy, and/or immunotherapy.
• Participants who have signed the consent form to participate in the study.
• Participants must have been evaluated in the Perioperative Evaluation and Management (POEM) Center or by a staff Anesthesiologist.
• All laboratory and diagnostic evaluations required or used to evaluate the patient must be completed. All participants must be approved to undergo anesthesia by the standards of the POEM Center.
• No samples belonging to vulnerable populations (children, pregnant women, cognitively impaired adults or prisoners) will be allowed from participation.

You may not qualify if…

• Participant is under age 18.
• Participant is unwilling to sign consent.
• Participant is unable to exercise (bedridden or wheel chair bound).
• Participant is enrolled in another study deemed by the investigator to affect oxygen metabolic efficiency and not presently the standard of care at MDACC.
• Participant's condition is deemed unsatisfactory for surgery after the preanesthetic evaluation.
• Participant has had a myocardial infarction within three months of the preanesthetic evaluation or presents with new or unstable angina.
• Participant has a history of a cerebrovascular accident or transit ischemic attacks within three months of the preanesthetic evaluation.
• Participant has a history of a pulmonary embolic event within three months of the preanesthetic evaluation.
• Participant is known to have acute or chronic deep vein thrombosis.
• Participant is pregnant.

Where it is running

• University of Texas MD Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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