Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?

Completed · Not applicable

Conditions studied: Osteoarthritis, Post-traumatic; Arthrosis

In brief

Prior to surgery, a pharmacist will randomly assign participating patients to one of two groups. One group will get an injection in the knee during surgery that contains medications to limit pain and an antibiotic. A second group will get an injection in the knee during surgery that contains the same pain medications and antibiotic along with a corticosteroid to control inflammation. Corticosteroids are anti-inflammatory medications, not to be confused with muscle-building anabolic steroids you may have heard about in the news. Each patient will have an equal chance of being in either of the two groups. This study will test the safety and efficacy of methylprednisolone acetate in the treatment of pain and inflammation following total knee replacement.

Key facts

Study ID

NCT00492973

Run by

New Lexington Clinic

People needed

101

Starts

2006-03-01

Expected to finish

2008-02-01

Last updated by the study team

2013-12-19

Who can join

Age: 18 and older, up to 95. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Between ages of 18 and 95
• Has elected to undergo total knee replacement

You may not qualify if…

• Allergy to any of the medications used in the protocol
• History of kidney disease
• Rheumatoid arthritis
• Any systemic conditions associated with chronic pain
• History of deep knee sepsis in the affected extremity
• Unable to understand the questions used to obtain the Knee Society Score
• Minors and prisoners will be excluded from the study

Where it is running

• Lexington Clinic Sports Medicine Center — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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