Periodontal and Periapical Inflammation and Pregnancy

Completed

Conditions studied: Periodontal Disease, Periapical Disease, Pregnancy, Diabetes, Cardiovascular Disease, Dental Caries

In brief

This is a retrospective chart review of patient records at the University of Mississippi Medical Center. We are not actively recruiting patients for this study. Recent animal studies we conducted showed that periapical abscesses during pregnancy cause a systemic inflammatory response in the mother. Also due to the increase in TNF-alpha (an inflammatory cytokine) the mother also become insulin resistant and thus developed gestational diabetes. Periodontal inflammation has been shown in the research to lead to low-birth weight and pre-term birth. We are looking retrospectively to see if an association exists in charted data between periapical and periodontal inflammation and adverse pregnancy outcomes.

Key facts

Study ID

NCT00490165

Run by

Roger Johnson

People needed

30

Starts

2007-03-01

Expected to finish

2011-12-01

Last updated by the study team

2012-04-06

Who can join

Age: 10 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Female
• Child bearing age or above

You may not qualify if…

• Male
• Very young children (before child-bearing age)

Where it is running

• University of Mississippi Medical Center — Jackson, Mississippi, United States

Full record on ClinicalTrials.gov

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