Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors

Stopped early · Not applicable

Conditions studied: Hypothyroidism, Brain Tumor

In brief

Primary Objectives: 1. Assess whether combined treatment with Levothyroxine and Liothyronine improves learning and memory. 2. Explore the relationship between T3 treatment and other domains of cognitive function, quality of life, and mood.

Key facts

Study ID

NCT00488644

Run by

M.D. Anderson Cancer Center

People needed

12

Starts

2006-02-01

Expected to finish

2010-03-01

Last updated by the study team

2013-06-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients must have the diagnosis of hypothyroidism.
• Patients must be already on thyroid hormone replacement.
• Patients must be greater than or equal to 18 years old.
• Patients must have a diagnosis of a primary or secondary brain tumor and must have received prior radiation.
• Patients must have a life expectancy of at least 6 months.

You may not qualify if…

• Previously established dementing illness.
• Other medical conditions known to cause dementia.
• Significant psychiatric illness.
• Uncontrolled seizures.
• Acute or chronic pulmonary disease.
• Active severe infections.
• Signs or symptoms of coronary artery disease.
• History of congenital hypothyroidism, hyperthyroidism, thyroidectomy, 131I-therapy, or thyroid cancer.
• Paroxysmal supraventricular tachycardia, or any serious unstable medical condition.
• Inability to read and write in English.
• Patients must not be taking any medications that interfere with thyroid hormone metabolism (Beta-Adrenergic Blocking Agents, Antiarrhythmic drugs, Antipsychotic Agents, Tricyclic Antidepressants, Amiodarone, Iodine, Lithium, and Alpha-Interferon).

Where it is running

• UT MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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