Glucose Metabolism in the Immediate and Short Term Follow up After Bariatric Surgery

Completed · Phase 1

Conditions studied: Diabetes, Gastric Bypass

In brief

MIDAS involves an assessment of glucose levels obtained before and after bariatric surgery. There are two different procedural tests involved; an oral glucose tolerance test (mixed meal) and a hyperglycemic clamp test. Two tests are performed preoperatively and five more are performed postoperatively for a one year period. The associated labwork drawn with the mixed meal and clamp tests are demonstrating changes in glucose, insulin and gut hormone levels.

Key facts

Study ID

NCT00488423

Run by

The Cleveland Clinic

People needed

21

Starts

2006-11-01

Expected to finish

2008-11-01

Last updated by the study team

2011-06-22

Who can join

Age: 19 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Negative pregnancy test if female
• ADA criteria for diabetes type II
• Hematocrit > 35 creatinine < 1.9, AST < 3X upper limit of normal, ALT < 3X upper limit of normal, alkaline phos <3X upper limit of normal
• Eligibility for bariatric surgery based on the NIH and clinical criteria
• Mentally and legally capable of providing consent

You may not qualify if…

• Lactating females
• Must not have type I diabetes
• Systemic steroids taken within 6 months
• Clinically significant heart disease
• Recent pulmonary embolism, untreated proliferative retinopathy, renal failure, uncontrolled hypertension, autonomic neuropathy, resting heart rate > 100, neuromuscular or musculoskeletal disease.

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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