Normal Lacritin Levels in Human Tears- Development of a New Clinical Assay
Completed
Conditions studied: Tear Protein Lacritin in Human Tears
In brief
Purpose: to build a library of normal tear lacritin values by collecting tears from normal adult human subjects and to develop a non-invasive clinical assay for lacritin. Such an assay will provide more sensitive indicators of eye disease for clinicians and determine if a particular therapy, such as recombinant lacritin drops, is of benefit.
Key facts
- Study ID
- NCT00487643
- Run by
- Walter Reed Army Medical Center
- People needed
- 100
- Starts
- 2008-05-01
- Expected to finish
- 2014-03-01
- Last updated by the study team
- 2014-07-11
Who can join
Age: 21 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Military health care beneficiary between the ages of 21-55.
- Male or female, of any race, and at least 21 years old and not older than 55 years old at the time of tear collection.
- Appropriately aged individuals who report that their eyes are "normal" and who have no active eye illness as determined by principal investigator or sub-investigator.
- Ability and willingness to understand and provide informed consent to participate in this study.
You may not qualify if…
- Irritated eye reflected by patient statements or finding of "red" eye.
- Individuals with any infections or inflammatory ocular condition (e.g. have "pink eye" or uveitis).
- Individuals diagnosed with dry eye or other ocular surface condition, including but not restricted to neurotrophic keratitis, anterior basement membrane dystrophy, and recurrent corneal erosions.
- Individuals who are on any topical eye medications.
- Anyone who reports previous reaction or the possibility of an allergic reaction to 0.5% proparacaine.
Where it is running
- Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
Full record on ClinicalTrials.gov
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