Early Diagnosis of Melanoma Using Expression Profiling and Non-Invasive Sampling of Skin Cells

Stopped early · Not applicable

Conditions studied: Melanoma

In brief

This study is divided into distinct sample collection and analysis phases. In the sample collection phase investigators will tape strip lesions that are designated for biopsy because they are suspected for melanoma. No biopsies will be taken solely in support of this study; rather patients that present lesions that are to be biopsied-in the context of the standard of care-will be enrolled in the study and will have that lesion(s) tape stripped before the biopsy procedure. In the second phase of the study, tape strip samples will be extracted and RNA purified and expression profiled by DNA microarray. The gene expression data will be correlated with histopathology with the expectation that an expression classifier that distinguishes suspect lesions from melanoma can be defined. That classifier will be validated in future studies.

Key facts

Study ID

NCT00482105

Run by

University of California, Davis

People needed

7

Starts

2007-03-01

Expected to finish

2008-08-01

Last updated by the study team

2015-04-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The subject will be eligible if he or she:
• Is at least 18 years of age;
• Has a pigmented lesion that is suspected of being a melanoma and requires surgical removal.

You may not qualify if…

• The subject cannot participate in this study if he or she:
• Has used topical medications (corticosteroids, alpha-hydroxyacids, or retinoids) within 30 days of beginning the research study;
• Has generalized skin disorders not related to skin cancer such as psoriasis, photosensitivity disorder or eczema;
• Has allergy to tape or latex rubber.

Where it is running

• UC Davis Department of Dermatology — Sacramento, California, United States

Full record on ClinicalTrials.gov

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