Evaluating the Role of Thrombin in Saphenous Vein Graft Failure After Heart Bypass Surgery

Status unconfirmed

Conditions studied: Coronary Artery Bypass, Thrombosis

In brief

Heart bypass surgery, also known as coronary artery bypass graft (CABG) surgery, creates a detour around the blocked part of a heart artery to restore blood supply to the heart muscle. The saphenous vein, located along the inside of the leg, is commonly used to create the bypass in a CABG surgery. An abnormal increase in the blood clotting protein thrombin may cause the saphenous vein graft to close up and eventually fail. This study will evaluate the relationship between thrombin levels and saphenous vein graft failures in people undergoing a CABG procedure.

Key facts

Study ID

NCT00481806

Run by

University of Arizona

People needed

450

Starts

2007-02-01

Expected to finish

2013-12-01

Last updated by the study team

2013-05-10

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Scheduled for CABG surgery at University of Arizona University Medical Center (UMC)
• For females, willing to use a reliable form of birth control for the duration of the study

You may not qualify if…

• Non-dermatologic allergy to intravenous (IV) radiographic contrast
• Creatinine levels greater than 2.0 mg/dL
• Pregnant

Where it is running

• University of Arizona College of Medicine — Tucson, Arizona, United States (enrolling)

Full record on ClinicalTrials.gov

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