fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

Completed

Conditions studied: Magnetic Resonance Imaging, Alzheimer's Disease, Dementia, Adult Children, Risk

In brief

The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors.

Key facts

Study ID

NCT00478491

Run by

University of Wisconsin, Madison

People needed

390

Starts

2003-01-01

Expected to finish

2011-07-01

Last updated by the study team

2016-10-27

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• MCI Group: Diagnosis of mild cognitive impairment
• AD Family History Group: Confirmed family history of Alzheimer's and concurrent enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
• Control Groups: Cognitively healthy and both parents survived past age 70 with no memory problems

You may not qualify if…

• Claustrophobia
• Metallic or electronic implants or devices that are not MRI-safe

Where it is running

• University of Wisconsin - Wisconsin Comprehensive Memory Program — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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