Pulmonary Hypertension in Trisomy 21 Patients

Completed

Conditions studied: Congenital Disorders

In brief

Evidence has shown poor outcome for adult patients with pre-operative pulmonary hypertension following closure of an atrial septal defect. Life-threatening pulmonary hypertensive crises may occur in these patients when they no longer have an atrial communication to decompress high right heart pressures. This concern has led some to advocate fenestrated patch closure of ASDs in patients with pulmonary hypertension with the prospect of a repeated procedure in order to close the fenestrations at a later date.

Key facts

Study ID

NCT00478296

Run by

Children's Healthcare of Atlanta

People needed

1

Starts

2004-10-01

Expected to finish

2008-03-01

Last updated by the study team

2012-03-16

Who can join

Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• case report of a patient with trisomy 21 and primum atrial septum defect with associated cleft mitral valve who was diagnosed with pulmonary hypertension at 8 days of life

You may not qualify if…

• those who do not fit into inclusion criteria

Where it is running

• Children's Healthcare of Atlanta — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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