Effect of Treating Sleep Apnea on Cognition in Patients With Dementia
Completed · Not applicable
Conditions studied: Dementia, Sleep Apnea
In brief
The purpose of this study is to determine whether treating sleep apnea with continuous positive airway pressure would result in improvements in cognition in patients with Alzheimer's disease.
Key facts
- Study ID
- NCT00477828
- Run by
- University of California, San Diego
- People needed
- 61
- Starts
- 2000-04-01
- Expected to finish
- 2006-01-01
- Last updated by the study team
- 2007-05-24
Who can join
Age: 50 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Mild probable Alzheimer's disease (diagnosed according to the National Institute of Neurological and Communicative Disorders \& Stroke-Alzheimer's Disease and Related Disorders Association [NINCDS-ADRDA] criteria).
- Mini Mental Status Exam score between 20 and 27
- Respiratory disturbance index >15 (i.e., 15 apneas plus hypopneas per hour of sleep) - Between the ages of 50-85 years
- Stable health
- reliable caregiver
- English speaking
- Patients will be allowed to continue acetylcholinesterase inhibitors, psychotropic medications, memory enhancers, health food supplements, etc. as long as they have been stable on the same dose for at least two months prior to participation and agree to continue on this dose for the duration of the study.
You may not qualify if…
- Currently receiving treatment for sleep apnea.
- Apneas primarily central in origin; narcolepsy or other sleep disorders
- Medication known to influence sleep (i.e. sedative hypnotics, narcotics) will be excluded if the dose can not remain stable and unchanged for the duration of the study.
- Bronchospastic and symptomatic chronic obstructive pulmonary disease as indicated by regular use of bronchodilators, steroids, history of carbon dioxide retention, waking hypoxemia (PaO2 <60 mmHg or SpO2 <92 % by pulse oximetry), or use of supplemental oxygen.
- Symptomatic coronary or cerebral vascular disease (history of myocardial infarction, angina, stroke, or transient ischemic attacks), history of life-threatening arrhythmias, cardiomyopathy, history of psychosis, or current alcohol or drug abuse
- Current diagnosis of active uncontrolled seizure disorder
- Any other advanced, severe and unstable disease of any type that may put the subject at special risk or interfere with primary and secondary variable evaluations
- Change in any medication within one month of participation.
Where it is running
- University of California San Diego — San Diego, California, United States
Full record on ClinicalTrials.gov
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