Effects of Stem Cell Transplantation on Bacteria in the Mouth
Completed
Conditions studied: Allogeneic Peripheral Blood Stem Cell Transplant
In brief
This study will examine bacteria in patients mouths at different times during stem cell transplantation and recovery. Drugs patients receive as part of the conditioning process for a stem cell transplant increase their risk of infection. There might be a link between the bacteria in the mouth and the bacteria that can cause infections. Knowing the changes in bacteria might help researchers determine the best method to prevent infections. Patients 18 years of age and older who are scheduled to receive a stem cell transplant may be eligible for this study. Participants undergo the following procedures: Review of medical records Interview about their oral care Oral examination Collection of oral specimens just before the stem cell transplant, immediately after the transplant, and 3 weeks after the transplant. The specimens are obtained as follows: * \<TAB\>-About one-fourth teaspoon of saliva is collected with a suction device similar to that used in a dental office. * \<TAB\>-Plaque from the surface of a tooth is collected with a plastic toothpick. * \<TAB\>-Skin cells from the inside of the cheek and the surface of the tongue are collected with a small soft brush. * \<TAB\>-If a tube is inserted into the patient s lungs to assist breathing and the patient is admitted to the intensive care unit, a specimen from the lungs is collected. Patients are followed for 100 days after their transplant. Additional oral specimens are obtained from those who develop signs and symptoms of respiratory infection.
Key facts
- Study ID
- NCT00476450
- Run by
- National Institutes of Health Clinical Center (CC)
- People needed
- 50
- Starts
- 2007-05-16
- Expected to finish
- 2016-03-07
- Last updated by the study team
- 2017-10-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Patients who have had recent oral surgery or oral trauma will be excluded.
- Patients with tracheostomies will also be excluded.
- Patients with sickle cell disease or chronic granulomatous disease who are being transplanted will be excluded from the protocol.
- Patients who are less than 18 years of age will be excluded.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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