ALL Adult Consortium Trial: Adult ALL Trial
Completed · Phase 2
Conditions studied: Acute Lymphoblastic Leukemia
In brief
The purpose of this study is to determine the safety and effectiveness of a multi-drug chemotherapy regimen in adult patients with Acute Lymphoblastic Leukemia (ALL). We will use a regimen that is often used in pediatric patients and we will add drugs called PEG-asparaginase and E. coli asparaginase. PEG-asparaginase has been given as an injection in the past and has been used in treatment with both children and adults with ALL. Information from those other research studies suggests that intravenous PEG-asparaginase has been administered safely in both children and adults. We hope to gain more information about the participants disease and how it responds to standard chemotherapy drugs used to treat ALL\>
Key facts
- Study ID
- NCT00476190
- Run by
- Dana-Farber Cancer Institute
- People needed
- 112
- Starts
- 2007-04-01
- Expected to finish
- 2020-03-01
- Last updated by the study team
- 2025-06-12
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Acute lymphoblastic leukemia, excluding known mature B-cell ALL by the presence of any of the following: surface immunoglobulin, L3 morphology, t(8;14)(q24;q32), t(8;22), or t(2;8)
- Age 18.00-50.99 years
You may not qualify if…
- Prior anti-leukemic therapy except 1 week or less of steroids, and/or emergent radiation therapy to the mediastinum, or hydroxyurea or emergent leukopheresis
- Known HIV positive
- Secondary ALL
- Pregnant or breast feeding women
- Patients with an active psychiatric or mental illness making informed consent or careful clinical follow-up unlikely
Where it is running
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Children's Hospital of Boston — Boston, Massachusetts, United States
- Beth Isreal Deaconess Medical Center — Boston, Massachusetts, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center — New York, New York, United States
- Ohio State University Medical Center — Columbus, Ohio, United States
- LDS Hospital — Salt Lake City, Utah, United States
- Vancouver Cancer Center — Vancouver, British Columbia, Canada
- Cancer Care Manitoba — Winnipeg, Manitoba, Canada
- The Moncton Hospital — Moncton, New Brunswick, Canada
- QEII, Health Sciences Centre — Halifax, Nova Scotia, Canada
- Hopital Charles LeMoyne — Greenfield Park, Quebec, Canada
- Hopital Maisonneuve Rosemont — Montreal, Quebec, Canada
- Hopital Notre-Dame — Montreal, Quebec, Canada
- McGill University Department of Oncology — Montreal, Quebec, Canada
Full record on ClinicalTrials.gov
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