A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure

Completed · Phase 3 · Has a placebo group

Conditions studied: Heart Decompensation

In brief

The purpose of this study is to find out if nesiritide (a human B-type natriuretic peptide/hBNP) as compared to placebo, plus the usual treatment for acute decompensated heart failure, helps to improve breathing difficulties, reduce heart failure readmissions to hospitals, and helps patients live longer.

Key facts

Study ID

NCT00475852

Run by

Scios, Inc.

People needed

7141

Starts

2007-05-01

Expected to finish

2011-03-01

Last updated by the study team

2013-03-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Hospitalized for the management of acute decompensated heart failure (ADHF) or diagnosed with ADHF within 48 hours after being hospitalized for another reason; Diagnosis of ADHF is defined as dyspnea (difficulty breathing) at rest or dyspnea with minimal activity.

You may not qualify if…

• At high risk for hypotension (low blood pressure); Acute coronary syndrome as primary diagnosis; History of cardiac valvular stenosis, restrictive cardiomyopathy, hypertrophic cardiomyopathy, or pericardial tamponade; Previous enrollment in a nesiritide study; Persistent, uncontrolled hypertension (SBP [systolic blood pressure] >180 mmHg).

Where it is running

• Study site — Mobile, Alabama, United States
• Study site — Anchorage, Alaska, United States
• Study site — Gilbert, Arizona, United States
• Study site — Scottsdale, Arizona, United States
• Study site — Fort Smith, Arkansas, United States
• Study site — Jonesboro, Arkansas, United States
• Study site — Berkeley, California, United States
• Study site — Culver City, California, United States
• Study site — Escondido, California, United States
• Study site — Inglewood, California, United States
• Study site — Loma Linda, California, United States
• Study site — Los Angeles, California, United States
• Study site — Mission Viejo, California, United States
• Study site — Sacramento, California, United States
• Study site — San Diego, California, United States
• Study site — Santa Ana, California, United States
• Study site — Torrance, California, United States
• Study site — Ventura, California, United States
• Study site — Denver, Colorado, United States
• Study site — Englewood, Colorado, United States
• Study site — Fort Collins, Colorado, United States
• Study site — Hartford, Connecticut, United States
• Study site — New Haven, Connecticut, United States
• Study site — Newark, Delaware, United States
• Study site — Huntsville, Alabama, United States

Full record on ClinicalTrials.gov

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