The Pharmacokinetics of a Single Large Dose of Vitamin D3
Completed · Not applicable
Conditions studied: Vitamin D Deficiency
In brief
When people eat a meal, some, but not all of the calcium in that meal is absorbed, that is, moved into the bloodstream. When the skin is exposed to sunlight during summer months, Vitamin D is made there and then modified into more active forms by the liver and kidneys. These more active forms of Vitamin D improve calcium absorption. Many adults living in the U.S. have little or no sun exposure and are low in Vitamin D. A single dose of 100,000 IU of Vitamin D3 has been used both as empiric treatment for Vitamin D deficiency as well as in controlled trials without risk of raising blood calcium to dangerous levels.This study is to determine the serum levels of Vitamin D and 25-hydroxyvitamin D (vitamin D after it has been modified by the liver) that can be expected when Vitamin D3 is given as a single oral dose of 100,000 IU.
Key facts
- Study ID
- NCT00473239
- Run by
- Creighton University
- People needed
- 40
- Starts
- 2006-10-01
- Expected to finish
- 2007-03-01
- Last updated by the study team
- 2015-05-04
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- healthy with limited sun exposure of less than 10 hours per week and daily milk consumption of less than 0.47 L (16 oz.).
You may not qualify if…
- those with granulomatous conditions, liver disease, kidney disease, or diabetes and those taking anticonvulsants, barbiturates, or steroids in any form.
Where it is running
- Creighton University — Omaha, Nebraska, United States
Full record on ClinicalTrials.gov
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