The Effects of Reducing Stomach Acid on Post-tonsillectomy Pain
Stopped early · Phase 4 · Has a placebo group
Conditions studied: Post-tonsillectomy Pain, Post-tonsillectomy Activity, Post-tonsillectomy Hydration
In brief
This study was designed to determine whether post-operative pain following a tonsillectomy can be reduced by adding an antacid-like medication to the medications taken after surgery. It is hypothesized that even a small amount of stomach acid backing up and entering the mouth can increase post-tonsillectomy pain. Therefore, the use of an antacid-like medication should help to decrease pain and reduce the amount of narcotic medication required for pain control.
Key facts
- Study ID
- NCT00472186
- Run by
- Boston Children's Hospital
- People needed
- 2
- Starts
- 2008-06-01
- Expected to finish
- 2011-02-01
- Last updated by the study team
- 2021-12-06
Who can join
Age: 5 and older, up to 18. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- All healthy children ages 5-18 years scheduled for tonsillectomy and /or adenotonsillectomy for sleep disturbance secondary to airway obstruction at Children's Hospital Boston
You may not qualify if…
- Patients on any medications other than the study drug (Lansoprazole or placebo), Amoxicillin®, and acetaminophen with or without codeine
- An underlying medical condition which would necessitate an alteration in the anesthetic regimen
- Patients allergic to any of the medications in the protocol
- History of chronic tonsillitis
- History of chronic pain conditions
- History of active gastro-esophageal reflux disease
- Surgery in addition to tonsillectomy/adenotonsillectomy (except for myringotomy)
- Cognitive/developmental disorders
- Inability to use a self-report pain scale
Where it is running
- Children's Hospital Boston — Boston, Massachusetts, United States
- Childrens Hospital Boston — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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