Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

Completed

Conditions studied: Turner Syndrome, Ovarian Failure, Premature, Sex Chromosome Aberrations, Menopause, Perimenopause

In brief

Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition. From preliminary data, we suspect that women with Turners syndrome (45, XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of ocular surface disease. Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen and androgen) alterations posed by POF and TS.

Key facts

Study ID

NCT00471731

Run by

National Eye Institute (NEI)

People needed

72

Starts

2007-05-07

Expected to finish

2014-11-13

Last updated by the study team

2018-02-14

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may not qualify if…

• Persons less than 18 years old.
• Persons with ophthalmic diseases associated with ocular surface disease.
• Hyperprolactinemia.
• Cushing s syndrome.
• Other endocrine disorders which impact sex steroid hormones.
• AIDS
• Pregnancy or lactation.
• For age matched control population ONLY- complaints of dry eye.
• For age matched control population ONLY- oral contraceptives or menopausal hormone therapy or any medications which alter sex hormone levels in the blood or chronic usage of medications that induce dry eye.

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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