Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Cancer Patients
Completed · Phase 3 · Has a placebo group
Conditions studied: Neurotoxicity, Pain, Peripheral Neuropathy, Unspecified Adult Solid Tumor, Protocol Specific
In brief
RATIONALE: Topical cream containing amitriptyline and ketamine may help relieve pain, numbness, tingling, and other symptoms of peripheral neuropathy. It is not yet known whether topical amitriptyline and ketamine cream is more effective than a placebo in treating peripheral neuropathy caused by chemotherapy. PURPOSE: This randomized phase III trial is studying the side effects and how well topical amitriptyline and ketamine cream work compared with a placebo in treating peripheral neuropathy caused by chemotherapy in patients with cancer.
Key facts
- Study ID
- NCT00471445
- Run by
- Gary Morrow
- People needed
- 462
- Starts
- 2007-10-01
- Expected to finish
- 2013-11-01
- Last updated by the study team
- 2015-11-09
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- MBCCOP - Hawaii — Honolulu, Hawaii, United States
- MBCCOP - University of Illinois at Chicago — Chicago, Illinois, United States
- CCOP - Central Illinois — Decatur, Illinois, United States
- CCOP - Evanston — Evanston, Illinois, United States
- CCOP - Wichita — Wichita, Kansas, United States
- CCOP - Grand Rapids — Grand Rapids, Michigan, United States
- CCOP - Metro-Minnesota — Saint Louis Park, Minnesota, United States
- CCOP - Nevada Cancer Research Foundation — Las Vegas, Nevada, United States
- CCOP - Hematology-Oncology Associates of Central New York — East Syracuse, New York, United States
- CCOP - North Shore University Hospital — Manhasset, New York, United States
- CCOP - Southeast Cancer Control Consortium — Winston-Salem, North Carolina, United States
- CCOP - Columbia River Oncology Program — Portland, Oregon, United States
- CCOP - Greenville — Greenville, South Carolina, United States
- CCOP - Upstate Carolina — Spartanburg, South Carolina, United States
- CCOP - Virginia Mason Research Center — Seattle, Washington, United States
- CCOP - Northwest — Tacoma, Washington, United States
- CCOP - Marshfield Clinic Research Foundation — Marshfield, Wisconsin, United States
Full record on ClinicalTrials.gov
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