Quantification of Intramyocardial Lipid by Proton Magnetic Resonance Spectroscopy

Completed · Not applicable

Conditions studied: Heart Transplantation

In brief

Accumulation of triglycerides in heart tissue has been associated with changes in left ventricular function which can lead to heart failure. Proton magnetic resonance spectroscopy is currently the only non-invasive in vivo method to measure myocardial triglycerides content. The primary goal of this study was to determine if Magnetic Resonance Spectroscopy could effectively measure myocardial triglyceride content in myocardial heart tissue. Thus, quantitative and reliable techniques to monitor in vivo triglyceride accumulation in the heart are important for disease diagnosis and management. Currently, no such imaging method exists.

Key facts

Study ID

NCT00469911

Run by

Washington University School of Medicine

People needed

18

Starts

2005-08-01

Expected to finish

2009-06-01

Last updated by the study team

2018-09-13

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy volunteers
• heart transplant patients
• undergoing post transplant endomyocardial biopsy
• not experiencing significant rejection
• heart transplant patients must be 18-30 years old.

You may not qualify if…

• <18 or >45
• pregnant
• significant systemic illness
• actively ill
• acute transplant rejection
• any condition that would prevent a participant from completing the NMR spectroscopy (i.e pacemakers, claustrophobia)

Where it is running

• Washington University Medical School — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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