Lestaurtinib, Cytarabine, and Idarubicin in Treating Younger Patients With Relapsed or Refractory Acute Myeloid Leukemia
Completed · Phase 1/Phase 2
Conditions studied: Leukemia
In brief
RATIONALE: Lestaurtinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cytarabine and idarubicin, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving lestaurtinib together with cytarabine and idarubicin may kill more cancer cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of lestaurtinib when given together with cytarabine and idarubicin and to see how well they work in treating younger patients with relapsed or refractory acute myeloid leukemia.
Key facts
- Study ID
- NCT00469859
- Run by
- Children's Oncology Group
- People needed
- 14
- Starts
- 2007-06-01
- Expected to finish
- 2010-03-01
- Last updated by the study team
- 2017-03-15
Who can join
Age: 1 and older, up to 30. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham — Birmingham, Alabama, United States
- Children's Hospital of Orange County — Orange, California, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
- Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
- Indiana University Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute — Boston, Massachusetts, United States
- C.S. Mott Children's Hospital at University of Michigan Medical Center — Ann Arbor, Michigan, United States
- Masonic Cancer Center at University of Minnesota — Minneapolis, Minnesota, United States
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis — St Louis, Missouri, United States
- Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center — New York, New York, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- Knight Cancer Institute at Oregon Health and Science University — Portland, Oregon, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States
- Vanderbilt-Ingram Cancer Center — Nashville, Tennessee, United States
- Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas — Dallas, Texas, United States
- Baylor University Medical Center - Houston — Houston, Texas, United States
- Children's Hospital and Regional Medical Center - Seattle — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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