Insulin Secretion in Diabetes Before and After Glycemic Control
Completed · Not applicable
Conditions studied: Diabetes, Hyperglycemia
In brief
The objective of this project is to understand defects in insulin secretion that contribute to abnormal glucose metabolism in patients with diabetes. In particular the effects of signals released from the intestine to stimulate insulin secretion will be tested. Patients with type 2 diabetes will have insulin secretion in response to glucose and intestinal factors before and after insulin treatment to lower their blood glucose. It is expected that the results of this work will provide valuable information for treating diabetic people.
Key facts
- Study ID
- NCT00469833
- Run by
- US Department of Veterans Affairs
- People needed
- 17
- Starts
- 2008-04-01
- Expected to finish
- 2012-09-01
- Last updated by the study team
- 2015-01-15
Who can join
Age: 30 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Aim 1:
- (non-diabetics)
- male/female 30-65 yrs old,
- free of active medical disease,
- no history of diabetes.
- (diabetics)
- HbA1c=6.5-8.5,
- treated with metformin, a sulfonylurea, or combination,
- Stable body wt with BMI 28-40.
- Aim 2: Same as above
- Aim 3: Diabetic with HgA1c 8.0-9.5
You may not qualify if…
- Aim 1: For both groups: no history of: pancreatitis, cardiac, gastrointestinal, renal or liver disease.
- Aim 2: Same as above
- Aim 3: Same as above, plus a diagnosis of incipient diabetic nephropathy severe nonproliferative, or proliferative retinopathy.
Where it is running
- VA Medical Center, Cincinnati — Cincinnati, Ohio, United States
Full record on ClinicalTrials.gov
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