Modulation of Plasmacytoid Dendritic Cell Function in Multiple Sclerosis
Completed
Conditions studied: Multiple Sclerosis
In brief
The purpose of this study is to determine whether interferon-beta impairs the ability of plasmacytoid dendritic cells to promote pathogenic immune responses in patients with multiple sclerosis.
Key facts
- Study ID
- NCT00468182
- Run by
- Rutgers, The State University of New Jersey
- People needed
- 24
- Starts
- 2007-04-01
- Expected to finish
- 2011-12-01
- Last updated by the study team
- 2015-05-07
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Males and females, 18 to 60 year old, inclusive.
- Diagnosis of a relapsing form of multiple sclerosis as determined by revised McDonald Criteria or at least one clinical demyelinating episode with abnormal brain MRI study based on CHAMPS criteria
- Expanded disability status scale (EDSS) score less than 6 at entry.
- Understand and sign written informed consent prior to any testing under this protocol, including screening tests and evaluations that are not considered part of the subject's routine care.
You may not qualify if…
- Treatment with corticosteroids within one month prior to the study. Treatment with immunomodulatory drugs within last 3 months prior to the study.
- No history of treatment with Interferon-beta(IFN-beta) based drugs to exclude the possibility of IFN-beta neutralizing antibodies
- Any patient who is pregnant, intend to become pregnant, or breastfeeding at any time of the study.
- History of any significant cardiac, gastrointestinal, hepatic, pulmonary, or renal disease; immune deficiency; or other medical conditions that would preclude IFN-beta therapy.
- Primary Progressive Multiple Sclerosis patients or patients with Secondary Progressive Multiple Sclerosis with lack of recent clinical relapses for more than 2 years
Where it is running
- Rutgers-RWJMS — New Brunswick, New Jersey, United States
Full record on ClinicalTrials.gov
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