Effect of Burn Size on Cytomegalovirus Reactivation and Correlates of T Cell Immune Function in Burned Patients

Completed

Conditions studied: Burns, Cytomegalovirus

In brief

The purpose of this study is to evaluate the effect of burn injury on the human immune system with a focus on cytomegalovirus (CMV) reactivation and the immunologic correlates of latent viral reactivation. Subjects will be patients admitted to the North Carolina Jaycee Burn Center with burn injury. Blood samples will be collected over time and will be evaluated for CMV reactivation and immune cell phenotype.

Key facts

Study ID

NCT00467532

Run by

University of North Carolina, Chapel Hill

People needed

60

Starts

2007-03-01

Expected to finish

2011-03-01

Last updated by the study team

2013-01-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Burn injury,
• Positive CMV IgG level confirmative of previous CMV infection and latency.

You may not qualify if…

• Immunocompromising conditions including HIV/AIDS,
• End-stage renal disease,
• End-stage liver disease,
• Pregnancy,
• Rheumatologic or collagen-vascular disease requiring chronic use of steroids,
• Chronic use of immunosuppressive agents,
• Recent chemotherapy, and
• History of solid organ or allogeneic stem cell transplant.

Where it is running

• North Carolina Jaycee Burn Center, UNC Hospitals — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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