Use of Donepezil for Treatment of Cocaine Dependence

Completed · Phase 2 · Has a placebo group

Conditions studied: Cocaine Abuse and Dependence

In brief

The purpose of this study is to determine the safety of intravenous cocaine in subjects receiving oral donepezil.

Key facts

Study ID

NCT00467389

Run by

US Department of Veterans Affairs

People needed

12

Starts

2007-02-01

Expected to finish

2008-09-01

Last updated by the study team

2014-06-09

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Non-treatment seeking, experienced cocaine users, who have used cocaine by smoking or intravenous injection within the four weeks prior to screening, and must supply a cocaine-positive urine obtained within four weeks of entry into the study.

You may not qualify if…

• Shows signs of psychostimulant toxicity, or has a history of a medical adverse reaction to cocaine or other psychostimulants, including loss of consciousness, chest pain, cardiac ischemia, or seizure.
• Has a current psychiatric disorder other than drug abuse or dependence or dementia.
• Meets the Diagnostic and Statistical Manual of Mental Disorders-IV criteria for dependence to opiates, benzodiazepines, alcohol, or other sedative-hypnotics.
• Has received opiate-substitution therapy (methadone or buprenorphine) within two months prior to enrollment.
• Has current or past history of seizure disorder, including alcohol- or psychostimulant- related seizures, or family history of seizure disorder.
• Has a diagnosis of adult asthma, or chronic obstructive pulmonary disease, including a history of acute asthma within the past two years, and those with current or recent (with the past two years) treatment with an inhaled or oral beta-adrenergic agonist.
• Has had head trauma that resulted in neurological sequelae.
• Has an unstable medical condition, which, in the judgement of investigators, would make participation hazardous.

Where it is running

• VA Medical Center — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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