Treatment of Aggression, Anger and Emotional Dysregulation in Borderline Personality Disorder

Completed · Not applicable

Conditions studied: Borderline Personality Disorder

In brief

This study examines the effects of 12 months of dialectical behavior therapy (DBT) for subjects with borderline personality disorder on aggression, anger and emotional dysregulation. Treatment effects will be measured by changes in interview, self-report, psychophysiology testing and fMRI neuroimaging.

Key facts

Study ID

NCT00467038

Run by

US Department of Veterans Affairs

People needed

22

Starts

2006-11-01

Expected to finish

2010-09-01

Last updated by the study team

2015-08-25

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Able to provide written informed consent
• In good physical health as confirmed by a complete physical exam, electrocardiogram, neurological exam, and routine laboratory tests of blood and urine
• A negative urine toxicology screen
• Completion of psychiatric evaluations, medical evaluations, and self-report questionnaires through separate protocol- Biological Correlates of Personality Disorders (GCO #88-244)
• meet DSM-IV criteria for borderline personality disorder and have an overt aggression scale- modified aggression subscale score of six or above on one of two OASM pre-treatment screens.
• not currently be taking any psychiatric medications. If they have taken psychiatric medications in the past, they must be at least 2 weeks (6 half-lives) medication-free prior to participating in the study. These medications include mood stabilizers, antidepressants, antipsychotics, and benzodiazepines.

You may not qualify if…

• meet criteria for schizophrenia, bipolar I disorder, schizoaffective disorder or any other psychotic disorder.
• have met criteria for substance abuse or dependence during the 6 months prior to entry into the study
• have a past history of intravenous drug use, cocaine abuse or dependence, or any substance dependence that resulted in serious medical sequelae
• meet criteria for current MDE, as they may require antidepressant treatment
• have made a suicide attempt or had a psychiatric hospitalization during the 6 months prior to entry into the study
• be on any psychotropic medication(s) upon entry into the study
• be in concurrent psychotherapy (case management services and work therapy programs are not considered individual psychotherapy)
• be pregnant or lactating

Where it is running

• VA Medical Center, Bronx — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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