Acamprosate vs. Placebo in Bipolar Alcoholics

Completed · Phase 4 · Has a placebo group

Conditions studied: Alcohol Dependence, Bipolar Disorder

In brief

To conduct a double-blind, randomized, placebo-controlled outpatient clinical trial of acamprosate in individuals with alcohol dependence and bipolar disorder who are also receiving mood stabilizing medication. The study will assess the safety and efficacy of acamprosate in alcohol-dependent bipolar patients as measured by its effects on alcohol use and mood symptoms relative to placebo. The primary hypothesis to be tested is whether individuals with comorbid bipolar disorder and alcohol dependence who receive acamprosate plus mood stabilizer will have greater improvement in alcohol-related outcomes than those who receive mood stabilizer alone. A secondary hypothesis that will be explored is that alcohol-dependent bipolar individuals treated with acamprosate will have greater mood stability as compared to those treated with mood stabilizers alone.

Key facts

Study ID

NCT00466661

Run by

Medical University of South Carolina

People needed

33

Starts

2007-04-01

Expected to finish

2010-02-01

Last updated by the study team

2018-12-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults ages 18-65
• Meet DSM-IV criteria for current (past 90 days) alcohol dependence
• Meet DSM-IV criteria for bipolar I or bipolar II disorder
• Currently on a mood stabilizing medication regimen, including the use of lithium, valproic acid, lamotrigine, carbamazepine, and/or antipsychotic agent FDA approved to treat bipolar disorder without any dosage adjustments in the past 30 days
• Must be able to remain free from alcohol for at least 3 days prior to medication initiation
• Subjects must be able to adequately provide informed consent and function at an intellectual level sufficient to allow the accurate completion of all assessment instruments
• Subjects must consent to random assignment and be willing to commit to medication treatment and follow-up assessments

You may not qualify if…

• Individuals with a primary psychiatric disorder other than bipolar disorder
• Individuals with an uncontrolled neurologic condition that could confound the results of the study
• Individuals with an uncontrolled medical condition that may adversely affect the conduct of this trial or jeopardize the subject's safety
• Participants with creatinine clearance less than or equal to half of normal value as indicated by chem. 7 results conducted at screening visit.
• Concomitant use of other psychotropic medications not allowed per the protocol
• Women of childbearing potential who are pregnant, lactating or refuse to use adequate forms of birth control
• Current suicidal or homicidal risk
• Baseline scores of > 35 on the Montgomery Asberg Depression Rating Scale and/or > 25 on the Young Mania Rating Scale

Where it is running

• Institute of Psychiatry, Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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