3T Perfluorocarbon-Filled Endorectal Magnetic Resonance Spectroscopic Imaging of Prostate

Stopped early · Not applicable

Conditions studied: Prostate Cancer

In brief

Objectives: The objectives of this study are to: 1) evaluate the feasibility of 3T MRSI of prostate in improving the spectral resolution, using a PFC-filled endorectal coil, 2) develop a systematic metabolic grading system for tumor detection by identifying the abnormal peak areas of Cho, Cr, Po, and Ci for the prostate carcinoma, specifically from PFC-filled endorectal 3T MRSI, and 3) evaluate the efficacy of the metabolic grading system in tumor detection. The long-term goal of the study is to provide an early prognostic indicator and means of monitoring the biologic status of the prostate cancer during the course of the disease.

Key facts

Study ID

NCT00464724

Run by

M.D. Anderson Cancer Center

People needed

90

Starts

2007-03-01

Expected to finish

2019-12-12

Last updated by the study team

2020-02-10

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Biopsy proven, clinical stage 1-3 prostate carcinomas
• Prostatectomy at M. D. Anderson within 3 months from the time of MRSI
• An interval of > 6 weeks between the biopsy and MRSI
• Signed informed consent form

You may not qualify if…

• Contraindications for MRI (e.g. cardiac pacemaker)
• Contraindications for MRS (e.g. history of abdomino-perineal resection of rectum)
• Metals or any conditions (e.g. hip prosthesis) that can distort the local magnetic field
• Previous prostate surgery for prostate carcinoma (including, TURP and cryosurgery), local or systemic treatment for prostate carcinoma (e.g. radiation, androgen deprivation), pelvic radiation (e.g. rectal cancer), rectal surgery, BCG for bladder cancer

Where it is running

• University of Texas MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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