Glycoprotein and Glycan in Tissue and Blood Samples of Patients With Stage IB-IVA Cervical Cancer Undergoing Surgery to Remove Pelvic and Abdominal Lymph Nodes

Completed

Conditions studied: Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Small Cell Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Stage IB Cervical Cancer, Stage IIA Cervical Cancer, Stage IIB Cervical Cancer, Stage III Cervical Cancer, Stage IVA Cervical Cancer

In brief

This clinical trial studies glycoprotein and glycan in tissue and blood samples of patients with stage IB-IVA cervical cancer undergoing surgery to remove pelvic and abdominal lymph nodes. Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer. It may also help doctors learn how far the disease has spread.

Key facts

Study ID

NCT00460356

Run by

Gynecologic Oncology Group

People needed

159

Starts

2007-04-02

Expected to finish

2016-07-16

Last updated by the study team

2017-08-24

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients with primary, previously untreated, histologically confirmed locoregionally advanced (Stages IB2, IIA > 4 cm, IIB-IVA) invasive carcinoma of the cervix (any cell type) who will undergo pelvic and para-aortic (abdominal) lymphadenectomy to determine the presence or absence of lymph node metastasis
• Patients who have met the pre-entry requirements
• Patients with a block or 25 unstained sections of formalin-fixed and paraffin-embedded primary tumor available to satisfy the primary tumor requirement
• Patients who have signed an approved informed consent and authorization permitting release of personal health information

You may not qualify if…

• Patients who do not satisfy pre-entry requirements

Where it is running

• UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California, United States
• Olive View-University of California Los Angeles Medical Center — Sylmar, California, United States
• Augusta University Medical Center — Augusta, Georgia, United States
• Wayne State University/Karmanos Cancer Institute — Detroit, Michigan, United States
• Saint Louis University Hospital — St Louis, Missouri, United States
• Sunrise Hospital and Medical Center — Las Vegas, Nevada, United States
• Women's Cancer Center of Nevada — Las Vegas, Nevada, United States
• Montefiore Medical Center-Einstein Campus — The Bronx, New York, United States
• Summa Akron City Hospital/Cooper Cancer Center — Akron, Ohio, United States
• University of Cincinnati/Barrett Cancer Center — Cincinnati, Ohio, United States
• Case Western Reserve University — Cleveland, Ohio, United States
• Cleveland Clinic Cancer Center/Fairview Hospital — Cleveland, Ohio, United States
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• Hillcrest Hospital Cancer Center — Mayfield Heights, Ohio, United States
• Lake University Ireland Cancer Center — Mentor, Ohio, United States
• University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
• Oklahoma Cancer Specialists and Research Institute-Tulsa — Tulsa, Oklahoma, United States
• Women and Infants Hospital — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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