Zinc & Bone Health in Thalassemia: The Think Zinc Study

Completed · Not applicable · Has a placebo group

Conditions studied: Thalassemia

In brief

The purpose of this study is to test whether zinc can improve bone health in young patients with thalassemia.

Key facts

Study ID

NCT00459732

Run by

UCSF Benioff Children's Hospital Oakland

People needed

45

Starts

2006-04-01

Expected to finish

2011-02-01

Last updated by the study team

2020-12-04

Who can join

Age: 6 and older, up to 30. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 6 to 30 years of age
• thalassemia
• bone mineral density Z-score < -1.0 (by DXA)

You may not qualify if…

• Bone marrow transplant recipient
• Currently prescribed treatment for low bone mass other than calcium or vitamin D (e.g. calcitonin, bisphosphonates)
• Currently prescribed zinc supplementation who are unable or unwilling to stop during this trial
• Currently participating in another trial with a medication known to affect bone mineral density.
• Chronic use of systemic corticosteroids
• Untreated hypogonadism or growth hormone deficiency
• Baseline serum copper < 70 µg/dL
• Baseline vitamin D-25OH < 11 ng/mL
• Pregnant or lactating at study entry

Where it is running

• Children's Hospital & Research Center, Oakland — Oakland, California, United States
• University of California, San Francisco — San Francisco, California, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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