PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive Patients With (MCMD)

Stopped early · Not applicable

Conditions studied: HIV-Dementia, HIV-Associated Cognitive Motor Complex, AIDS Encephalopathy, AIDS Dementia Complex, AIDS-Related Dementia Complex, HIV Infections, Healthy

In brief

The purpose of this protocol is to measure a receptor in the brain using positron emission tomography (PET) that is involved in inflammation.

Key facts

Study ID

NCT00459693

Run by

National Institute of Mental Health (NIMH)

People needed

40

Starts

2007-04-09

Expected to finish

2014-04-06

Last updated by the study team

2020-09-10

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Current psychiatric illness or severe systemic disease based on history and physical exam
• Current dependence on alcohol or substances other than nicotine.
• Laboratory results from blood or urine tests that show clinically significant abnormalities.
• Previous radiation exposure (X-rays, PET scans etc.) that would exceed research limits.
• Pregnancy and breast feeding.
• A history of brain disease.
• Cannot lie on your back for long periods since the pictures will be taken for about 2.5 hours during which time you will have to lie still on the scanner bed.
• More than moderate hypertension.
• Positive result on urine screen for illicit drugs.

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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