Safety of and Immune Response to a Meningitis Vaccine in HIV-Infected Children and Youth

Completed · Phase 1/Phase 2

Conditions studied: HIV Infections, Meningitis

In brief

Bacterial meningitis infection is common in youth 2 to 24 years of age in the United States. This disease can be treated by antibiotics, but mortality rates associated with meningitis of up to 53% have been estimated. Vaccination against meningitis may be effective in preventing this disease, especially for HIV-infected youth who have weakened immune systems. The purpose of this study was to determine the safety of and immune response to a preventive meningitis vaccine in HIV-infected youth.

Key facts

Study ID

NCT00459316

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

384

Starts

2007-06-01

Expected to finish

2013-03-01

Last updated by the study team

2021-11-03

Who can join

Age: 2 and older, up to 24. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Usc La Nichd Crs — Alhambra, California, United States
• Miller Children's Hosp. Long Beach CA NICHD CRS — Long Beach, California, United States
• Children's Hospital of Los Angeles NICHD CRS — Los Angeles, California, United States
• UCLA-Los Angeles/Brazil AIDS Consortium (LABAC) CRS — Los Angeles, California, United States
• University of California, UC San Diego CRS — San Diego, California, United States
• Univ. of California San Francisco NICHD CRS — San Francisco, California, United States
• Harbor UCLA Medical Ctr. NICHD CRS — Torrance, California, United States
• Univ. of Colorado Denver NICHD CRS — Aurora, Colorado, United States
• Children's National Med. Ctr. Washington DC NICHD CRS — Washington D.C., District of Columbia, United States
• Howard Univ. Washington DC NICHD CRS — Washington D.C., District of Columbia, United States
• South Florida CDTC Ft Lauderdale NICHD CRS — Fort Lauderdale, Florida, United States
• Univ. of Florida Jacksonville NICHD CRS — Jacksonville, Florida, United States
• Pediatric Perinatal HIV Clinical Trials Unit CRS — Miami, Florida, United States
• USF - Tampa NICHD CRS — Tampa, Florida, United States
• Rush Univ. Cook County Hosp. Chicago NICHD CRS — Chicago, Illinois, United States
• Ann & Robert H. Lurie Children's Hospital of Chicago (LCH) CRS — Chicago, Illinois, United States
• Tulane Univ. New Orleans NICHD CRS — New Orleans, Louisiana, United States
• Univ. of Maryland Baltimore NICHD CRS — Baltimore, Maryland, United States
• Children's Hosp. of Boston NICHD CRS — Boston, Massachusetts, United States
• Boston Medical Center Ped. HIV Program NICHD CRS — Boston, Massachusetts, United States
• WNE Maternal Pediatric Adolescent AIDS CRS — Worcester, Massachusetts, United States
• Children's Hospital of Michigan NICHD CRS — Detroit, Michigan, United States
• Rutgers - New Jersey Medical School CRS — Newark, New Jersey, United States
• Nyu Ny Nichd Crs — New York, New York, United States
• Metropolitan Hosp. NICHD CRS — New York, New York, United States

Full record on ClinicalTrials.gov

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