The Vascular Effects of Carvedilol Controlled Release (CR) in Abdominally Obese Hypertensive Patients
Completed · Phase 3
Conditions studied: Abdominal Obesity, Hypertension
In brief
The purpose of this study is to compare the effects of two different combination therapies for high blood pressure on vascular health.
Key facts
- Study ID
- NCT00459056
- Run by
- St. Paul Heart Clinic
- People needed
- 25
- Starts
- 2007-04-01
- Expected to finish
- 2010-05-01
- Last updated by the study team
- 2013-12-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- >18 years old
- Systolic blood pressure (SBP) >130 and/or diastolic blood pressure (DBP) >85 (or currently taking anti-hypertensive medication)
- Waist circumference >102 cm (men) and >88 cm (women)
- Stable cardiovascular medication regimen (or other medications known to affect endothelial function) at least 1 month prior to enrollment and throughout the study
You may not qualify if…
- Use of anti-hypertensive medications within one month of randomization (patients may be washed-out from anti-hypertensive medications)
- Unstable angina
- History of angina symptoms within 3 months of screening
- Decompensated heart failure
- History of myocardial infarction
- Stroke or coronary artery bypass graft within 3 months of screening
- Standard clinical contraindications to beta-blocker therapy
- Standard clinical contraindications to ACE-I therapy
- Women who are currently pregnant or planning to become pregnant (pregnancy testing will occur at specific intervals throughout study and women will be informed of potential risks during the consenting process; information specific to this risk will be detailed in the consent form)
- Breastfeeding women
- Clinically significant liver disease
- Creatinine > 2.5 mg/dL
- Hepatic function greater than 3 times upper limit of normal
Where it is running
- St. Paul Heart Clinic — Saint Paul, Minnesota, United States
Full record on ClinicalTrials.gov
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