Comparing Two Pneumococcal Vaccines in Adults With Chronic Obstructive Pulmonary Disease

Completed · Phase 3

Conditions studied: Pulmonary Disease, Chronic Obstructive

In brief

Pneumococcal disease is a serious bacterial infection that can affect different parts of the body, including the lungs. People with chronic illnesses, such as chronic obstructive pulmonary disease (COPD), have a greater risk of developing pneumonia and meningitis as a result of pneumococcal disease. This study will compare the immune response to two types of pneumococcal vaccines in adults with COPD.

Key facts

Study ID

NCT00457977

Run by

University of Minnesota

People needed

181

Starts

2007-03-01

Expected to finish

2011-05-01

Last updated by the study team

2015-05-12

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosis of Chronic Obstructive Pulmonary Disease (COPD)
• Post-bronchodilator forced expiratory volume at one second
• /forced vital capacity (FEV1/FVC) level less than 70%
• Ten or more pack-years of smoking
• Willing to make return visits to the study clinic and accept telephone contact
• Last pneumococcal vaccination occured at least 5 years prior to study entry

You may not qualify if…

• Asthma
• Sensitivity to pneumococcal vaccine
• Known bleeding disorder, or requires long-term anticoagulation therapy
• Presence of chronic disease that may impair pneumococcal vaccine response
• Acute illness requiring antibiotics in the month prior to study entry
• Medical condition that makes survival for 24 months following study entry unlikely
• Pregnant

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• Veteran's Administration Medical Center — Birmingham, Alabama, United States
• LA BioMed at Harbor, University of California — Los Angeles, California, United States
• University of California San Francisco-Airway Clinical Research Center — San Francisco, California, United States
• Denver Health Medical Center — Denver, Colorado, United States
• National Jewish Medical and Research Center — Denver, Colorado, United States
• Veteran's Administration Medical Center — Denver, Colorado, United States
• University of Maryland Hospital — Baltimore, Maryland, United States
• Fallon Clinic — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Veteran's Administration Medical Center — Boston, Massachusetts, United States
• Veteran's Administration Medical Center — Ann Arbor, Michigan, United States
• University of Michigan Medical Center — Ann Arbor, Michigan, United States
• Veteran's Administration Medical Center — Minneapolis, Minnesota, United States
• HealthPartners Research Foundation — Minneapolis, Minnesota, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Temple University Lung Center — Philadelphia, Pennsylvania, United States
• University of Pittsburgh Emphysema Research Center — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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