Aricept to Improve Functional Tasks in Vascular Dementia

Status unconfirmed · Phase 1

Conditions studied: Stroke, Vascular Dementia, Memory Deficits

In brief

Medications for memory improvement are available but they may not actually improve the ability to do real world tasks. The purpose of this research study is to determine if a medicine used to treat memory problems donepezil(Aricept) enhances the ability to remember steps of functional tasks and the actual ability to perform tasks relevant to real-life independence. Aricept is an FDA approved medication for the treatment of Alzheimer's disease. Aricept is an investigational drug for the purposes of this study, and is not approved for this purpose.

Key facts

Study ID

NCT00457769

Run by

Kessler Foundation

People needed

18

Starts

2007-05-01

Expected to finish

2021-12-01

Last updated by the study team

2021-02-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• I am 18 to100 yrs old.
• I had one stroke 4 months to 5 yrs ago
• I am not taking Aricept or other cholinesterase inhibitors (e.g. Exelon, Razadyne) or memantine (Namenda).

You may not qualify if…

• I have history of dementia and or have been diagnosed with a memory disorder prior to my stroke.
• I have been on anti-depressants or other cognitive enhancing drugs for less than 3 months and the dose is not stabilized yet.
• I consume alcohol more than or equivalent of 4 ounces hard liquor weekly.
• I am taking oral anticholinergic medications like Bethanechol, Bentyl or Detrol.
• I am a woman of childbearing potential or I am pregnant or a nursing mother.
• I have a history of chronic vomiting or diarrhea.
• I am allergic to Aricept.

Where it is running

• Kessler Foundation — West Orange, New Jersey, United States

Full record on ClinicalTrials.gov

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