The Effects of Exercise Versus Inactivity on People With Mitochondrial Muscle Disease
Status unconfirmed · Phase 2
Conditions studied: Mitochondrial Myopathy
In brief
Mitochondrial myopathies include various inherited diseases that are caused by damage to the mitochondria, energy-producing structures that fuel the body's processes. The main symptoms are muscle weakness, reduced muscle mass, and difficulty with exercising. The purpose of this study is to determine the effects of exercise training versus inactivity on mitochondrial function in muscle and muscle performance in people with mitochondrial myopathies.
Key facts
- Study ID
- NCT00457314
- Run by
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- People needed
- 50
- Starts
- 2007-06-01
- Expected to finish
- 2012-06-01
- Last updated by the study team
- 2009-05-19
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of mitochondrial myopathy
- Single-large scale deletions of mitochondrial DNA
- Point mutations in mitochondrial DNA
You may not qualify if…
- Symptoms or electrocardiogram-generated signs of coronary artery disease
- Symptoms of congestive heart failure; peripheral vascular disease; or lung, kidney, or liver disease
- History of alcohol or substance abuse
- Metal implants or related devices that contraindicate MRI
- Current use of or require any medications that have significant systemic cardiovascular effects
- Diabetes
- Obesity (body mass index [BMI] greater than 30)
- Resting systolic blood pressure greater than 140 mmHg and/or diastolic blood pressure greater than 90 mmHg at three different times
Where it is running
- University of Texas Southwestern Medical Center — Dallas, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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