Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment
Completed · Not applicable
Conditions studied: Depression
In brief
This study will use pre-treatment positron emission topography and functional magnetic resonance imaging scans of the brain to predict the most effective antidepressant treatment for people with major depressive disorder.
Key facts
- Study ID
- NCT00456014
- Run by
- New York State Psychiatric Institute
- People needed
- 37
- Starts
- 2006-09-01
- Expected to finish
- 2012-05-01
- Last updated by the study team
- 2019-03-19
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of current major depressive disorder
- Currently depressed
- Subjects must be generally healthy with no significant medical problems, anemia/blood loss, or cardiac abnormalities
- Likely to tolerate medication washout
- Capacity to provide informed consent
- Off of anti-coagulant/anti-platelet treatment for 10 days
- Willing to travel to Brookhaven for PET scanning
You may not qualify if…
- Current abuse of or dependence on alcohol or another substance (>6 months remission okay)
- History of other major psychiatric disorders such as bipolar, schizophrenia, schizoaffective; anorexia or bulimia in past year
- First degree family history of schizophrenia if subject is under 33
- Unable/unwilling to discontinue all psychotropic medication that affects the serotonin system
- Pregnant, breastfeeding, or planning to become pregnant during the study
- A medical contraindication to antidepressants
- Dementia
- Prior head trauma with evidence of cognitive impairment
- Well-documented failure of two or more SSRI AND tricyclic antidepressant (TCA) trials of adequate dose and duration
- Metal implants, pacemaker, metal protheses or orthodontic appliance, the presence of shrapnel
- Current past, present, or anticipated exposure to radiation
- Actively suicidal
- Lifetime history of glaucoma
- Lack of response to >2 trials of antidepressant monotherapy of adequate dose and duration
- Claustrophobia
Where it is running
- Columbia University/New York State Psychiatric Institute — New York, New York, United States
Full record on ClinicalTrials.gov
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