Mechanism of Growth Hormone Effects on Adipose Tissue

Completed · Phase 4

Conditions studied: Obesity

In brief

Growth hormone treatment in humans has been shown to decrease body fat. This study aims to determine what adipose tissue depots are affected by GH and what is the mechanism.

Key facts

Study ID

NCT00453557

Run by

Pennington Biomedical Research Center

People needed

30

Starts

1999-04-01

Expected to finish

2000-12-01

Last updated by the study team

2016-12-08

Who can join

Age: 40 and older, up to 70. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Male, aged 40-70
• Central obesity defined as waist circumference greater than 102 cm and BMI > 27 and < 35 kg/m2
• No weight loss in last 12 months
• Total IGF-1 level < 241 ng/ml (\~25th percentile for the assay)
• Body habitus which permitted accurate CT scan acquisition and analysis.

You may not qualify if…

• Significant neurologic, metabolic, endocrine, cardiac, respiratory or gastrointestinal disease
• Diabetes
• Known coronary heart disease
• Exercised more than 3 hours per week
• Unwilling or unable to abstain from alcohol for 72 hours prior to the measurements of energy expenditure and fasting blood work

Where it is running

• Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States

Full record on ClinicalTrials.gov

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