Changes in Eye Pressure and Anterior Chamber Depth With Oral Endothelin Antagonist Therapy

Completed

Conditions studied: Glaucoma, Pulmonary Hypertension

In brief

There is growing evidence that a cause of glaucoma is linked to circulatory problems and poor auto-regulation of blood flow to the optic nerve. Pulmonary hypertension (PH)is a disease characterized by low oxygen levels in the blood and altered blood circulation. The decrease in oxygen delivery to the optic nerve could lead to the loss of nerve fiber layer(NFL)in the retina and the resulting visual field compromise. This situation is characteristic of glaucoma. The ability to identify NFL thinning early could lead to earlier diagnosis of glaucoma and more effective treatment to limit dysfunction from visual field loss. We hypothesize that the rate of structural damage to the NFL, a feature of glaucoma, is higher in patients with PH than expected in healthy populations lacking this disease.

Key facts

Study ID

NCT00452283

Run by

University of Colorado, Denver

People needed

23

Starts

2007-03-01

Expected to finish

2011-05-01

Last updated by the study team

2013-01-31

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosed with pulmonary hypertension
• between the ages of 18 and 80 years
• ability to undergo the various ocular exams.

You may not qualify if…

• patients with other diseases that could affect the nerve fiber layer
• special populations; ie children, pregnancy, lactating females, prisoners

Where it is running

• University of Colorado Eye Center — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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