Exhaled Breath Condensate pH in Patients With Cough Caused by Gastroesophageal Reflux
Stopped early
Conditions studied: Cough, Gastroesophageal Reflux
In brief
Cough is the most common complaint for which patients seek medical attention in the United States, accounting for approximately 1 billion dollars in health care expenses annually. Gastroesophageal reflux disease (GERD) is the sole cause of chronic cough in up to 20-40% of all cases. The majority of these patients with GERD-induced cough have no classic "heartburn" symptoms, so this important cause of cough can thus be difficult to detect. Our hypothesis is that changes in exhaled breath condensate (EBC) pH can be used as a sensitive and non-invasive marker to identify subjects with cough caused by acid reflux.
Key facts
- Study ID
- NCT00451841
- Run by
- University of Massachusetts, Worcester
- People needed
- 30
- Starts
- 2007-03-01
- Expected to finish
- 2013-06-01
- Last updated by the study team
- 2018-06-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age > 18 years old
- able to speak and read English
- chronic cough
You may not qualify if…
- Cigarette smoking within the past 6 months, or greater than 10 pack year history of prior smoking
- Any self-reported or clinically diagnosed form of active lung disease, including asthma and emphysema
- Symptoms of persistent rhinitis within the past three months
- Dysphagia
- Symptoms of acute viral upper respiratory tract infection or sinusitis within one month of entry into the study
- Pregnancy - based on self report
- Abnormal chest radiograph
Where it is running
- UMass Memorial Medical Center, University Campus — Worcester, Massachusetts, United States
Full record on ClinicalTrials.gov
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