Six Month Study of Gentamicin in Duchenne Muscular Dystrophy With Stop Codons

Completed · Phase 1

Conditions studied: Duchenne Muscular Dystrophy

In brief

The purpose of this study is to determine the safety of giving intravenous (IV) gentamicin to boys with Duchenne muscular dystrophy who have stop codon mutations.

Key facts

Study ID

NCT00451074

Run by

Nationwide Children's Hospital

People needed

12

Starts

2007-03-01

Expected to finish

2009-07-01

Last updated by the study team

2012-03-23

Who can join

Age: 5 and older, up to 20. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Age 5-20 years
• Duchenne muscular dystrophy documented by written report of stop codon mutation analysis of the dystrophin gene.
• Subject is capable of cooperating for efficacy and safety testing
• Absent dystrophin on muscle biopsy
• Subjects may be untreated, taking prednisone or comparable corticosteroids
• Subjects taking corticosteroids must be on the same dose for at least 3 months (90 days) prior to the start of the study.

You may not qualify if…

• Known allergy to any aminoglycoside or sulfate compounds
• Current use of potential nephrotoxic or ototoxic drug
• Current use of corticosteroids has not been stable for 3 months (90) days
• Known mutation at nucleotide 1555 in 12S rRNA gene of mitochondrial DNA (predisposes to aminoglycoside hearing loss and commercially available via Athena Diagnostics Lab). This DNA testing (Hearing susceptibility test) will be made available through funding from this grant.
• Inability to hear within the range of 0 to 25 dB in any hearing frequency by pure tone audiometry
• Cystatin C equal to or > 1.4mg/L
• Other medical condition that would impede the conduct of study (e.g., congestive heart failure)

Where it is running

• Neuromuscular Research Institute - Scottsdale Healthcare Hopsital at Shea — Scottsdale, Arizona, United States
• University of Kansas — Kansas City, Kansas, United States
• The Research Institute at Nationwide Children's Hospital — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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