Evaluating Progression of and Diagnostic Tools for Primary Ciliary Dyskinesia in Children and Adolescents
Completed
Conditions studied: Primary Ciliary Dyskinesia
In brief
Mucociliary clearance, in which mucus secretions are cleared from the breathing airways, is the primary defense mechanism for the lungs. Inhaled particles, including microbes that can cause infections, are normally entrapped in mucus on the airway surfaces and then cleared out by the coordinated action of tiny hair-like structures called cilia. Individuals with primary ciliary dyskinesia (PCD) have defective mucociliary clearance, which in turn leads to lung infections and disease. The purpose of this study is to determine how lung disease progresses over time in children and adolescents with PCD.
Key facts
- Study ID
- NCT00450918
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 150
- Starts
- 2006-08-01
- Expected to finish
- 2019-08-01
- Last updated by the study team
- 2019-10-07
Who can join
Age: 5 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of PCD or probable PCD. More information about the criteria for a PCD diagnosis can be found in the protocol.
- Parent or guardian willing to provide informed consent
You may not qualify if…
- Inability to attend follow-up appointments
- Previously received lung transplant
- Any disease that may have significant impact on lung function (e.g., severe congenital heart disease, severe scoliosis), respiratory infections (e.g., AIDS), or overall health status (e.g., cancer, end-stage kidney disease)
- Pregnant or breastfeeding
Where it is running
- The Children's Hospital — Denver, Colorado, United States
- Washington University — St Louis, Missouri, United States
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
- Children's Hospital and Regional Medical Center — Seattle, Washington, United States
- The Hospital for Sick Children — Toronto, Ontario, Canada
Full record on ClinicalTrials.gov
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